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After 17 months, weight loss may reach 17% of the starting weight

Public Health Summary Keywords chronic constipation, depression, gut dysbiosis, microbiota-gut-brain axis, psychobiotics, short-chain fatty acids Citation Yu B, Zhao W, Tao L and Li K (2026) The microbiota-gut-brain axis perspective: mechanisms and intervention strategies for the comorbidity of chronic constipation and depression

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Compounded semaglutide (prepared by licensed compounding pharmacies) has been an option for some patients, but its availability fluctuates with FDA shortage status and it differs from the FDA-approved brand-name product